If the smell gets stronger, you carry on, and if not, you turn around. If you can’t smell any difference, you could set off in any random direction. You turn your head left and right to find out if the scent is stronger in one direction. “It’s comparable to picking up the scent of freshly baked bread. “The wound site probably releases a signal that the stem cells can sense,” says Werner. That’s why they simulate various movement strategies in a computer, using what’s known as a Cellular Potts model. Because this RNA is found only in specific cells, we can clearly see them glowing when observed under the microscope.”īut the researchers can only label cells in dead worms and therefore cannot track the movements of the stem cells within a worm. We can add a molecule that only binds to the RNA of such a gene and then emits a fluorescent light if we aim a laser beam at it. “We know genes that are only active in stem cells or in the cells which arise from these stem cells. The researchers dissect the worms and selectively label the cells so they can see what part of the body they are in.
The lab is full of containers of flatworms that are destined to help unravel these secrets. There are even species that reproduce by splitting themselves What’s the secret of these creatures: how do the stem cells get to the wound, and how do they know what they’re supposed to become?” There are even species that reproduce by splitting themselves. “Flatworms, in contrast, have a lot of versatile stem cells, which can become any type of flatworm cell,” says assistant professor Steffen Werner. “Thus, flatworms can endlessly regenerate themselves and in principle live forever unless they get sick or don’t find enough food. Adult stem cells behave very differently to their embryonic counterparts and for example are committed to distinct types of cells: blood stem cells make our blood, and stem cells in the skin make new skin cells. While stem cells organise themselves to generate all body parts during the development of a baby, adults cannot even regrow a missing fingertip. Stem cells produce all the other cells in our bodies. Many doctors and scientists dream of being able to grow a new and functional kidney, heart or liver from a patient’s stem cells.
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